Elements of Molecular Neurobiology by C. U. M. Smith

Product Description

This edition of the popular text incorporates recent advances in neurobiology enabled by modern molecular biology techniques. Understanding how the brain works from a molecular level allows research to better understand behaviours, cognition, and neuropathologies. Since the appearance six years ago of the second edition, much more has been learned about the molecular biology of development and its relations with early evolution. This "evodevo" (as it has come to be known) framework also has a great deal of bearing on our understanding of neuropathologies as dysfunction of early onset genes can cause neurodegeneration in later life. Advances in our understanding of the genomes and proteomes of a number of organisms also greatly influence our understanding of neurobiology.
* Well known and widely used as a text throughout the UK, good reviews from students and lecturers.
* Good complement to Fundementals of Psychopharmacology by Brian Leonard.
This book will be of particular interest to biomedical undergraduates undertaking a neuroscience unit, neuroscience postgraduates, physiologists, pharmacologists.
It is also a useful basic reference for university libraries.
Maurice Elphick, Queen Mary, University of London
"I do like this book and it is the recommended textbook for my course in Molecular Neuroscience. The major strength of the book is the overall simplicity of the format both in terms of layout and diagrams."
Product Details

* Amazon Sales Rank: #501745 in Books
* Published on: 2002-11-15
* Number of items: 1
* Binding: Paperback
* 630 pages

Editorial Reviews

Review
"…will prove very useful to every individual interested in molecular neurobiology research..." (Journal of Chemical Neuroanatomy, Vol.29, 2005)

Download Description
This thoroughly revised and updated new edition of C.U.M. Smith's 1996 text gives an account of the molecular biology of the brain as it stands at the beginning of the twenty-first century. While retaining the overall structure of the second edition, this new edition incorporates new material on: genomics; ion channels; neural stem cells; gap junctions; channelopathies; cannabinoids; DNA-chips manipulation of K+-channels; molecular bases of memory; motor neuron disease; Alzheimer's Disease.

Book Info
Aston Univ., Birmingham, UK. Comprehensive updated textbook gives an account of the molecular biology of the brain. Contains new topics on genomics, ion channels, neural stem cells, gap-junctions, channelopathies, cannabinoids, DNA-chips and molecular bases of memory. Softcover, hardcover available, listed in approval week 2003-12. Previous edition: c1989.

Calcium-Binding Protein Protocols: Volume 1: Reviews and Case Histories (Methods in Molecular Biology)

Product Description

Blurb for Volume 1

Hans Vogel and a panel of leading researchers review the protein chemistry and behavior of this significant protein class, and provide a comprehensive collection of proven experimental techniques for their study both in vitro and in vivo. This first volume discusses the role of calcium in intracellular secondary messenger activation mechanisms, including unique aspects of calcium chemistry and its utilization in diary proteins and blood clotting. Detailed case studies provide a wealth of valuable information about protein purification and characterization strategies, X-ray crystallography, and specific calcium-binding proteins and their modes of action. The second companion volume focuses on cutting-edge experimental methods for studying solution structure, stability, dynamics, calcium-binding properties, and biological activity of calcium-binding proteins in general.

Single Blurb for Both Volumes:
Hans Vogel and a panel of leading researchers review the protein chemistry and behavior of this significant protein class, and provide a comprehensive collection of proven experimental techniques for their study both in vitro and in vivo. The first volume discusses the role of calcium in intracellular secondary messenger activation mechanisms, including unique aspects of calcium chemistry and its utilization in dairy proteins and blood clotting. Detailed case studies provide a wealth of valuable information about protein purification and characterization strategies, X-ray crystallography, and specific calcium-binding proteins and their modes of action. The second volume focuses on cutting-edge experimental techniques for studying the solution structure, stability, dynamics, calcium-binding properties, and biological activity of calcium-binding protein in general. In addition to enzymatic assays and more routine spectroscopic and protein chemistry techniques, there are also NMR approaches, thermodynamic analyses, kinetic measurements such as surface plasmon resonance, strategies for amino acid sequence alignments, and fluorescence methods to study the distribution of calcium and calcium-binding proteins in cells.

Product Details
Amazon Sales Rank: #3184480 in Books
Published on: 2001-12-15
Number of items: 1
Binding: Hardcover
360 pages
Editorial Reviews

Book Info
Univ. of Calgary, Alberta, Canada. Features all major biophysical and protein methods to study calcium-binding proteins and includes a detailed discussion of calcium-binding proteins in vitro and in vivo. Many of the methods are also applicable to proteins not binding to calcium.

Molecular Basis of Thyroid Cancer (Cancer Treatment and Research) From Springer

Product Description


Thyroid cancer shows the fastest rate of increase in women in the USA. There is an urgent need to better understand its underlying causes, explore efficient and sensitive methods for its diagnosis, new methods of treatment and follow-up, based on the recent advances in technology.

Molecular Basis of Thyroid Cancer brings together top-flight experts from across the globe to consider present state of the art treatment and techniques and what the future holds. The product of this effort is invaluable to endocrinologists, particularly those with an interest in the thyroid, molecular oncologists, nuclear medicine physicians and those in biotechnology intent on devising innovative therapies for cancer.
Product Details
Amazon Sales Rank: #943025 in Books
Published on: 2005-01-14
Number of items: 1
Binding: Hardcover
444 pages
Editorial Reviews

Review

Doody Enterprises, Inc., 500 N. Michigan Ave. Suite 1410, Chicago, IL 60611, Tel:312-644-7640, anne@doody.com


Reviewers Expert Opinion: Ronald N Cohen, MD (University of Chicago Medical Center)


This book discusses and evaluates recent advances in the molecular basis of the pathogenesis and treatment of the various forms of thyroid cancer. The purpose is to convey a better understanding of the factors that cause thyroid cancer, as well as to explore novel strategies for its treatment, focusing on recent advances in molecular biology. There is a significant, and rapidly-growing, literature concerning the molecular biology of thyroid cancer, and this book is a welcome addition that allows these novel findings to be placed in perspective. There will be a relatively narrow audience for this book. In particular, it will appeal significantly more to thyroidologists than to general endocrinologists. In addition, it will be interesting to nuclear medicine physicians, pathologists, and oncologists if they have a specific interest in thyroid cancer. The book covers a wide range of topics, ranging from the pathology of thyroid tumors to specific molecular events in the pathogenesis of thyroid cancer. In this process, chapters devoted to specific molecules important in thyroid cancer are included. In addition, information on NIS, and how it relates to thyroid cancer imaging and treatment is discussed in detail. Finally, molecular genetics, for example the genetics of medullary thyroid cancer, is also included. The chapters are well written and informative, though there is occasional overlap. For physicians and scientists with a significant interest in thyroid cancer, this book is a welcome addition. It provides a wealth of interesting information, and I enjoyed it very much.

Molecular Embryology: Methods and Protocols (Methods in Molecular Biology) From Humana Press

Product Description

A comprehensive guide to cutting-edge methods used today across the dramatically growing field of molecular embryology. These powerful techniques take advantage of the most commonly used vertebrate experimental models: murine embryos for their genetics, chick embryos for in vivo manipulation, zebrafish for mutagenesis, amphibian embryos, and nonvertebrate chordates. The book emphasizes the most important methods of experimental molecular biology and the particular advantages of each different species. Detailed, easy-to-follow instructions, together with relevant background information and helpful tips, ensure easy reproducibility.

Product Details
Amazon Sales Rank: #2405483 in Books
Published on: 1999-01-15
Number of items: 1
Binding: Hardcover
756 pages
Editorial Reviews

Review
"This book has much to offer biologists interested in the molecular biology of developmental systems in a wide range of vertebrates."-Doody's Health Sciences Book Review Journal

"Universal techniques are well-written, complete, and easy to follow including in situ hybridization, differential display PCR, as well as standard protocols for library construction, Northern and Southern analyses. This would be an excellent addition to any developmental biology laboratory, university department, and especially good for graduate students and post-docs."-Teratology

"...this book is a tome, a necessity imposed on it by its breadth, both in terms of model organisms (mouse, chicken, amphibians, zebra fish and prochordates) and methods (surgery, retro-virology, in situ hybridization, molecular biology, immunohistochemistry, microscopy and photography.) The protocols are compact and clearly written, with ever-so-helpful hints (called notes) grouped at the end of each chapter. ...we encourage both teachers and researchers actively involved in experimental embryology to buy this book, put it on the shelf and let your students know it is there." - TINS

"Molecular Embryology provides an excellent source for understanding the strengths and weaknesses of the various vertebrate model organisms, and provides a ready source for highly useful protocols....The protocols are thoroughly described and are accompanied by helpful illustrations. Developmental biologists will be pleased to add this book to their collection, and will likely reference it often for its many useful protocols."- The Quarterly Review of Biology

"This book is of interest to embryologists, biologists and probably to some neonatologists and geneticists. It describes in detail the experimental use of animal embryos...A well illustrated and referenced text for specialists." - Journal of Endocrine Genetics

Book Info
King's College, London, UK. Comprehensive guide to the methods used in vertebrate molecular embryology. Includes protocols, background information, and tips for success. For researchers. Outline format.

E. coli Plasmid Vectors: Methods and Applications (Methods in Molecular Biology) (Methods in Molecular Biology) From Humana Press

Product Description

A comprehensive collection of readily reproducible techniques for the manipulation of recombinant plasmids using the bacterial host E. coli. The authors describe proven methods for cloning DNA into plasmid vectors, transforming plasmids into E. coli, and analyzing recombinant clones. They also include protocols for the construction and screening of libraries, as well as specific techniques for specialized cloning vehicles, such as cosmids, bacterial artificial chromosomes, l vectors, and phagemids. Common downstream applications such as mutagenesis of plasmids, recombinant protein expression, and the use of reporter genes, are also described.
Product Details

* Amazon Sales Rank: #1911971 in Books
* Published on: 2003-07-03
* Number of items: 1
* Binding: Hardcover
* 328 pages

Editorial Reviews

Review
...a scientific review and a methodological "cook-book" of high quality. It is truly a highly practical handbook, useful for all scientists working with gene cloning and manipulation." - Folia Microbiologica

"...a very useful addition to laboratories investigating plasmids per se, and for those employing plasmids as vectors for gene cloning." - Microbiology Today

Book Info
Univ. of California, Berkeley. Offers step-by-step protocols for the manipulation of recombinant DNA. Discusses cutting-edge methods to manipulate plasmids and techniques to clone DNA into plasmid vectors and transform E. coli. Outline format. Halftone illustrations. For researchers.

Genetics: An Issue of Immunology and Allergy Clinics (The Clinics: Internal Medicine) by Deborah Meyers

Product Description

Significant progress has been made in understanding the pathogenesis of many allergic disorders. In spite of the tremendous complexity, dramatic progress in the past few years has led to an improved understanding of the genetic contributions to allergic and immunoregulatory disorders. This issue is divided into four parts: reviews of positional cloned genes from family studies, gene-environment interactions, gene-by-gene interactions, and future directions.
Product Details

* Amazon Sales Rank: #1672761 in Books
* Published on: 2005-11-15
* Number of items: 1
* Binding: Hardcover
* 240 pages

Editorial Reviews

About the Author
Deborah Meyers, PhD

Modelling Metabolism with Mathematica by Peter Mulquiney

Product Description

With the advent of sophisticated general programming environments like Mathematica, the task of developing new models of metabolism and visualizing their responses has become accessible to students of biochemistry and the life sciences in general. Modelling Metabolism with Mathematica presents the approaches, methods, tools, and algorithms for modelling the chemical-dynamics of metabolic pathways. The authors explain the concepts underpinning the deterministic theory of chemical and enzyme kinetics, present a graded series of computer models of metabolic pathways leading up to that of the human erythrocyte, and document a consistent set of rate equations and associated kinetic parameters. The experimental and theoretical study of metabolism in mammalian cells has a long and fruitful history, but our understanding of cellular metabolism at the molecular level is far from complete. This book enables its readers to formulate their own models of time-dependent metabolic systems and aids them in the quest for the many fundamental and clinically relevant discoveries that remain to be made.
Product Details

* Amazon Sales Rank: #1793860 in Books
* Published on: 2003-05-14
* Number of items: 1
* Binding: Hardcover
* 328 pages

Editorial Reviews

Book Info
Univ. of Sydney, Australia. Textbook covers the approaches, methods, tools, and algorithms for modeling the chemical dynamics of metabolic pathways. Discusses the concepts underpinning the theory of chemical and enzyme kinetics. Also presents a series of computer models of metabolic pathways leading up to the human erythrocyte. For graduate and postgraduate students.

Molecular Biology Problem Solver: A Laboratory Guide by Alan S. Gerstein

Product Description

Most research in the life sciences involves a core set of molecular-based equipment and methods, for which there is no shortage of step-by-step protocols. Nonetheless, there remains an exceedingly high number of inquiries placed to commercial technical support groups, especially regarding problems.

Molecular Biology Problem Solver: A Laboratory Guide asks the reader to consider crucial questions, such as:
Have you selected the most appropriate research strategy?
Have you identified the issues critical to your successful application of a technique?
Are you familiar with the limitations of a given technique?
When should common procedural rules of thumb not be applied?
What strategies could you apply to resolve a problem?

A unique question-based format reviews common assumptions and laboratory practices, with the aim of offering a firm understanding of how techniques and procedures work, as well as how to avoid problems. Some major issues explored by the book's expert contributors include:
Working safely with biological samples and radioactive materials
DNA and RNA purification
PCR
Protein and nucleid acid hybridization
Prokaryotic and eukaryotic expression systems
Properly using and maintaining laboratory equipment
Product Details
Amazon Sales Rank: #1011495 in Books
Published on: 2001-08-24
Number of items: 1
Binding: Paperback
528 pages
Editorial Reviews

Review
"It will strengthen your ability to prevent, identify and solve problems in the lab..." (Medical Laboratory World, October 2001)

Medical Laboratory World, October 2001
"It will strengthen your ability to prevent, identify and solve problems in the lab..."

Book Info
Question-based format reviews common assumptions and laboratory practices, with the aim of offering an understanding of how techniques and procedures work, as well as how to avoid problems. For life scientists. Softcover.

Molecular Basis of Thyroid Cancer (Cancer Treatment and Research) From Springer

Product Description


Thyroid cancer shows the fastest rate of increase in women in the USA. There is an urgent need to better understand its underlying causes, explore efficient and sensitive methods for its diagnosis, new methods of treatment and follow-up, based on the recent advances in technology.

Molecular Basis of Thyroid Cancer brings together top-flight experts from across the globe to consider present state of the art treatment and techniques and what the future holds. The product of this effort is invaluable to endocrinologists, particularly those with an interest in the thyroid, molecular oncologists, nuclear medicine physicians and those in biotechnology intent on devising innovative therapies for cancer.
Product Details
Amazon Sales Rank: #2481399 in Books
Published on: 2005-01-14
Number of items: 1
Binding: Hardcover
444 pages
Editorial Reviews

Review

Doody Enterprises, Inc., 500 N. Michigan Ave. Suite 1410, Chicago, IL 60611, Tel:312-644-7640, anne@doody.com


Reviewers Expert Opinion: Ronald N Cohen, MD (University of Chicago Medical Center)


This book discusses and evaluates recent advances in the molecular basis of the pathogenesis and treatment of the various forms of thyroid cancer. The purpose is to convey a better understanding of the factors that cause thyroid cancer, as well as to explore novel strategies for its treatment, focusing on recent advances in molecular biology. There is a significant, and rapidly-growing, literature concerning the molecular biology of thyroid cancer, and this book is a welcome addition that allows these novel findings to be placed in perspective. There will be a relatively narrow audience for this book. In particular, it will appeal significantly more to thyroidologists than to general endocrinologists. In addition, it will be interesting to nuclear medicine physicians, pathologists, and oncologists if they have a specific interest in thyroid cancer. The book covers a wide range of topics, ranging from the pathology of thyroid tumors to specific molecular events in the pathogenesis of thyroid cancer. In this process, chapters devoted to specific molecules important in thyroid cancer are included. In addition, information on NIS, and how it relates to thyroid cancer imaging and treatment is discussed in detail. Finally, molecular genetics, for example the genetics of medullary thyroid cancer, is also included. The chapters are well written and informative, though there is occasional overlap. For physicians and scientists with a significant interest in thyroid cancer, this book is a welcome addition. It provides a wealth of interesting information, and I enjoyed it very much.

Calcium-Binding Protein Protocols: Volume 1: Reviews and Case Histories (Methods in Molecular Biology) From Humana Press

Product Description

Blurb for Volume 1

Hans Vogel and a panel of leading researchers review the protein chemistry and behavior of this significant protein class, and provide a comprehensive collection of proven experimental techniques for their study both in vitro and in vivo. This first volume discusses the role of calcium in intracellular secondary messenger activation mechanisms, including unique aspects of calcium chemistry and its utilization in diary proteins and blood clotting. Detailed case studies provide a wealth of valuable information about protein purification and characterization strategies, X-ray crystallography, and specific calcium-binding proteins and their modes of action. The second companion volume focuses on cutting-edge experimental methods for studying solution structure, stability, dynamics, calcium-binding properties, and biological activity of calcium-binding proteins in general.

Single Blurb for Both Volumes:
Hans Vogel and a panel of leading researchers review the protein chemistry and behavior of this significant protein class, and provide a comprehensive collection of proven experimental techniques for their study both in vitro and in vivo. The first volume discusses the role of calcium in intracellular secondary messenger activation mechanisms, including unique aspects of calcium chemistry and its utilization in dairy proteins and blood clotting. Detailed case studies provide a wealth of valuable information about protein purification and characterization strategies, X-ray crystallography, and specific calcium-binding proteins and their modes of action. The second volume focuses on cutting-edge experimental techniques for studying the solution structure, stability, dynamics, calcium-binding properties, and biological activity of calcium-binding protein in general. In addition to enzymatic assays and more routine spectroscopic and protein chemistry techniques, there are also NMR approaches, thermodynamic analyses, kinetic measurements such as surface plasmon resonance, strategies for amino acid sequence alignments, and fluorescence methods to study the distribution of calcium and calcium-binding proteins in cells.

Product Details
Amazon Sales Rank: #2993294 in Books
Published on: 2001-12-15
Number of items: 1
Binding: Hardcover
360 pages
Editorial Reviews

Book Info
Univ. of Calgary, Alberta, Canada. Features all major biophysical and protein methods to study calcium-binding proteins and includes a detailed discussion of calcium-binding proteins in vitro and in vivo. Many of the methods are also applicable to proteins not binding to calcium.

Molecular Biology Problem Solver: A Laboratory Guide by Alan S. Gerstein

Product Description

Most research in the life sciences involves a core set of molecular-based equipment and methods, for which there is no shortage of step-by-step protocols. Nonetheless, there remains an exceedingly high number of inquiries placed to commercial technical support groups, especially regarding problems.

Molecular Biology Problem Solver: A Laboratory Guide asks the reader to consider crucial questions, such as:
Have you selected the most appropriate research strategy?
Have you identified the issues critical to your successful application of a technique?
Are you familiar with the limitations of a given technique?
When should common procedural rules of thumb not be applied?
What strategies could you apply to resolve a problem?

A unique question-based format reviews common assumptions and laboratory practices, with the aim of offering a firm understanding of how techniques and procedures work, as well as how to avoid problems. Some major issues explored by the book's expert contributors include:
Working safely with biological samples and radioactive materials
DNA and RNA purification
PCR
Protein and nucleid acid hybridization
Prokaryotic and eukaryotic expression systems
Properly using and maintaining laboratory equipment
Product Details
Amazon Sales Rank: #897621 in Books
Published on: 2001-08-24
Number of items: 1
Binding: Paperback
528 pages
Editorial Reviews

Review
"It will strengthen your ability to prevent, identify and solve problems in the lab..." (Medical Laboratory World, October 2001)

Medical Laboratory World, October 2001
"It will strengthen your ability to prevent, identify and solve problems in the lab..."

Book Info
Question-based format reviews common assumptions and laboratory practices, with the aim of offering an understanding of how techniques and procedures work, as well as how to avoid problems. For life scientists. Softcover.

Molecular Biology of the Cell by Alberts Et Al.

Product Details
Amazon Sales Rank: #142970 in Books
Published on: 1994-03
Number of items: 1
Binding: Hardcover
1408 pages
Customer Reviews

great new edition
this has everything the 4th edition had plus the latest discoveries within the past 5 years.

Great, but Last 5 Chapters are Electronic
GREAT book, but the only problem is that the last 5 chapters are in PDF format on an attached CD rather than in print (they did this to make the book more portable). If you want the full print version, buy the Reference edition.

what you want is the fourth edition
I'm sure this book was great in the 90s, but this is the 21st century, when you can buy the fourth edition. There has been a ton of advancement between 1994 and 2002.

The Biogenesis of Cellular Organelles (Molecular Biology Intelligence Unit) by Chris Mullins

Product Description


The Biogenesis of Cellular Organelles represents a comprehensive summary of recent advances in the study of the biogenesis and functional dynamics of the major organelles operating in the eukaryotic cell. This book begins by placing the study of organelle biogenesis in a historical perspective by describing past scientific strategies, theories, and findings and relating these foundations to current investigations. Reviews of protein and lipid mediators important for organelle biogenesis are then presented, and are followed by summaries focused on the endoplasmic reticulum, Golgi, lysosome, nucleus, mitochondria, and peroxisome.

Product Details
Amazon Sales Rank: #2278780 in Books
Published on: 2004-10-13
Number of items: 1
Binding: Hardcover
192 pages