Human Drug Metabolism: An Introduction By Michael Coleman

Product Description

Drug metabolism is a core area of pharmacology. Before any drug can be licensed it is essential to know how the body metabolises the drug, and the short and long-term effects it has on the body. It is an area of rapid advancement, which brings together the fields of pharmacy, pharmacology and medicine.

This new text provides a concise, user-friendly introduction to drug metabolism that is ideal for undergraduates. Focusing on a conceptual understanding of the drug metabolism system, the book illustrates the basic mechanisms on how xenobiotics are detected, chemically modified and then eliminated from human systems.
Product Details
Amazon Sales Rank: #2373082 in Books
Published on: 2005-11-18
Number of items: 1
Binding: Hardcover
286 pages
Editorial Reviews

Review
"…a useful introductory text for the intended audience of students studying pharmacology and toxicology…" (Veterinary Pathology, November 2006)

"The author has certainly achieved his goal of providing an accessible introduction to human drug metabolism." (The Annals of Pharmacotherapy, June 2006)

"Armed with the knowledge contained in this book, we should all be well on the way" (Pharmaceutical Physician, May 2006)

"…useful for many who are just beginning to learn about drug metabolism…a good addition to many personal and school libraries." (Journal of Medicinal Chemistry, April 20, 2006)

"...thumbs up for ambition." (Chemistry World, 1st March 2006)

"Overall this is an interesting book that provides a rather comprehensive overview of drug metabolism in humans" (Journal of Medicinal Chemistry, 2006 Volume 49. No 8)

Download Description
Drug metabolism is a core area of pharmacology. Before any drug can be licensed it is essential to know how the body metabolises the drug, and the short and long-term effects it has on the body. It is an area of rapid advancement, which brings together the fields of pharmacy, pharmacology and medicine. This new text provides a concise, user-friendly introduction to drug metabolism that is ideal for undergraduates. Focusing on a conceptual understanding of the drug metabolism system, the book illustrates the basic mechanisms on how xenobiotics are detected, chemically modified and then eliminated from human systems.

From the Back Cover
Human Drug Metabolism: An Introduction provides an accessible introduction to human drug metabolism for those who already have some understanding of the life sciences. It focuses only on essential chemical detail and includes patient case histories to illustrate the clinical consequences of changes in drug metabolism and its impact on patient welfare.

After underlining the relationship between efficacy, toxicity and drug concentration, the book then considers how metabolising systems operate and how they impact upon drug concentration, both under drug pressure and during inhibition. Factors affecting drug metabolism, such as genetic polymorphisms, age and diet are discussed and how metabolism can lead to toxicity is explained. The book concludes with the role of drug metabolism in the commercial development of therapeutic agents as well as the pharmacology of some illicit drugs.
focuses on a conceptual understanding of drug metabolism
takes a user-friendly approach to the chemical aspect of drug metabolism
includes a wealth of diagrams and illustrations
provides strategies for maximising examination performance

Human Drug Metabolism: An Introduction will be an invaluable resource for students studying pharmacology, pharmacy, bio-molecular sciences, biochemistry, molecular biology, toxicology, dentistry and medicine in addition to healthcare professionals and postgraduates.
Customer Reviews

Best metabolism book on the market
As an instructor of drug metabolism, I have read a lot of metabolism texts. This text is especially relevant for pharmacy students and medical students, but also for graduate students in some fields (pharmacology, human toxicology, human biochemistry). It focuses on its title, "human drug metabolism", and is written very clearly.

The author is British and occasionally overdoes the British professorial humor, yet it is the most readable and accessible (and still accurate and in-depth) text on the market! My pharmacy students actually read it, rather than using it as a paper weight.

Very disappointed
I have never written a review before, but I was so disappointed that I decided to write this one. I found that material is presented in hard to understand format. Manuscript is supposed to be an introduction; however, it provides almost no background information related to biology, biochemistry or chemistry. Author lists numerous drugs, while providing hardly any information about their function or chemical structure. Quite complex phenomena are mentioned in one sentence, while author devotes half of the paragraph contemplating why students would find this information difficult.
Although I can't claim an expertise in writing, I rarely have been so annoyed by the writing style and the lack of content of the scientific text.