Cleanroom Design (Wiley Series in Mathematical Methods in Practice) From Wiley

Product Description

This book has been written by an international body of authors working in a variety of industries including electronics, biotechnology and pharmaceuticals, who discuss the considerations to be taken into account when designing cleanrooms. Three chapters describe how cleanrooms are designed for the principal manufacturing areas of microelectronics, pharmaceutical manufacturing and biotechnology. Other subjects covered are international design standards, the economics of cleanroom design, high efficiency air filtration, materials used in cleanroom construction, and the provision of clean gases and water. A unique feature of this new edition includes the application of cleanroom design technology to a mini environment such as a bench-top.
Product Details

* Amazon Sales Rank: #815066 in Books
* Published on: 2000-01
* Number of items: 1
* Binding: Hardcover
* 322 pages

Editorial Reviews

Review
"..it is good value for money and an essential guide for cleanroom designers, users and controllers...", European Journal of Parenteral Sciences, Volume 5, No.1

From the Back Cover
Demand for cleanrooms is flourishing as manufacturing becomes increasingly sophisticated. From computers and CD players to medicines and convenience foods, more and more products require high levels of contamination control. Fully revised and updated, Cleanroom Design, Second Edition presents the latest advances in the field. Written by a highly experienced team of international authors, the broad coverage encompasses the design of cleanrooms for the microelectronics, pharmaceutical, medical device and biotechnology industries. Features include:
* New chapter on the design of medical devices featuring configurations for heart pacemakers and aortic bioprostheses
* Examination of the international standards for the design of cleanrooms providing the designer with a concise information source
* Discussion of cost-efficiency and energy-saving concepts such as minimizing the air flow rate and the impact of mini-environments
* Section on high efficiency air filtration looking at filter standards and testing
* Practical guidance on construction materials and surface finishes, pipework design, the production and transmission of high purity gases and water purification techniques
Based on practical industrial experience, this clear and informative guide will be a boon to all involved in the design of cleanrooms.
Customer Reviews

Technical Resourcefulness4
I find this book giving good examples and guidelines for design of cleanroom for various types of facilities. Very comprehensive. However would like to have typical design method or calculation for designing the various requirements or selection for the cleanroom itself e.g. how to maintain or design for the pressure differential between 2 types of rooms or areas and the sizing for the various plant support system or facilities

Complexity in Biological Information Processing -No. 239 (Novartis Foundation Symposia) by Novartis Foundation

Product Description

Many human diseases arise from the malfunction of signalling components, in particular alterations of multiple components of an integrated signalling network. Experimental and computational tools to describe and quantify these changes are increasingly available, providing a wealth of data that can stimulate systematic analysis of the entire signalling network and enable prediction of disease states not easily recognizable from complex data sets.

This groundbreaking book explores the structural and temporal complexity in biological signalling exemplified in neuronal, immunological, humoral and genetic signal transduction networks. With discussions between experimentalists and theoretically oriented scientists, this book takes an interdisciplinary approach that may help switch the analysis of biological signalling from descriptive to predictive science and capture the behaviour of entire systems.

* Explores the structural and temporal complexity in biological signalling.
* Represents an unusual collocation of three different areas: immunology, cell signalling and neural networks.
* Contains interdisciplinary discussions between experimentalists and theoretically oriented scientists, in particular those working on computer simulations.

Product Details

* Amazon Sales Rank: #3272366 in Books
* Published on: 2001-10-15
* Number of items: 1
* Binding: Hardcover
* 258 pages

Editorial Reviews

Book Info
(Novartis Foundation) Presents the proceedings on the Symposium on Complexity in Biological Information Processing, held at the Kaiserin-Freidrich-Haus, Berlin, Germany, on July 4-6, 2000.

From the Back Cover
Many human diseases such as cancer, diabetes and neural disorders arise from the malfunction of signalling components. This is frequently not caused by a single defect but is due to alterations to multiple components of an integrated signalling network. Experimental tools to quantify such changes precisely and describe the interconnected multichain signalling pathways in health and disease in a time-resolved manner are becoming increasingly available, resulting in a exponential increase in detailed information. For the unaided human mind, classification of this wealth of data and understanding the implications for pathophysiology is getting more and more difficult. Computational tools are a prerequsiite for understanding of the complex interactions in biological information processing from the vast array of experimental data. These tools are starting to take shape. They have the potential to integrate many details into a systematic analysis of the entire signalling network and enable prediction of diease states not easily recognizable from complex data sets. This approach may thus help to switch the analysis of biological signalling from descrptive to predictive science and capture in a more general way the behaviour of entire systems. This groundbreaking book explores the structural and temporal complexity in biological signalling exemplified in neuronal, immunological, humoral and genetic signal transduction networks. It contains interdisciplinary discussions between experimentalists and theoretically oriented scientists, in particular those working on computer simulations. Synthesis of experiment, theory and simulation should help to explain disorders of the regulation of complex biological networks and may lead to a new understanding of many human diseases.

Conducting GCP- Compliant Clinical Research: A Practical Guide by Wendy Bohaychuk

Product Description

Conducting GCP-Compliant Clinical Research Wendy Bohaychuk and Graham Ball Good Clinical Research Practices, UK and Canada The overall aim of this work is to provide a reference book which describes the general framework for conducting GCP-compliant clinical research, particularly pharmaceutical industry clinical research. Wendy Bohaychuk and Graham Ball run a consultancy, GCRP Ltd., which has conducted over 820 GCP audits involving more than 200 companies in the last 10 years. More than 5,000 individuals have been involved in their training courses to help people perform GCP-compliant clinical research. They have authored several books and articles including:
* Standard operating procedures for investigators
* Standard operating procedures for sponsors and CROs
* GCP - an indexed reference
Drawing on their wealth of experience, they have produced this enlightening and practical reference work which fills an educational gap in the understanding of GCP at all levels. Written in concise language simple enough to be accessible to those new in the field, the dozens of real-life stories and detailed case studies at the end of each chapter make the book an invaluable resource for the more experienced, highlighting what can go wrong in a clinical study: A study of prostate cancer in the UK - An investigator brochure was not provided. The company argued that a brochure was unnecessary because the drug was already marketed. Indeed it was - for hypertension! A study of cardiovascular surgery in the UK - The consent dates were changed (by overwriting) to indicate that the patients had provided consent before the study started. The original dates post-dated the start of the study. A study of hypertension in Germany - The investigator brochure predated the study by nine years! Checklists are provided throughout the book to help monitors, auditors and investigators ensure that nothing important is overlooked. The authors present the topic of GCP with remarkable clarity, insight and enthusiasm emphasizing that this code of practice was not designed to make studies more difficult for investigators or more expensive for sponsors and CROs but, in the final analysis, to ensure the safety and well-being of study participants and future patients who will benefit from well-conducted, GCP-compliant studies.
Product Details

* Amazon Sales Rank: #1167537 in Books
* Published on: 1999-06-09
* Number of items: 1
* Binding: Hardcover
* 226 pages

Editorial Reviews

From the Back Cover
Conducting GCP-Compliant Clinical Research Wendy Bohaychuk and Graham Ball Good Clinical Research Practices, UK and Canada The overall aim of this work is to provide a reference book which describes the general framework for conducting GCP-compliant clinical research, particularly pharmaceutical industry clinical research. Wendy Bohaychuk and Graham Ball run a consultancy, GCRP Ltd., which has conducted over 820 GCP audits involving more than 200 companies in the last 10 years. More than 5,000 individuals have been involved in their training courses to help people perform GCP-compliant clinical research. They have authored several books and articles including:
* Standard operating procedures for investigators
* Standard operating procedures for sponsors and CROs
* GCP - an indexed reference
Drawing on their wealth of experience, they have produced this enlightening and practical reference work which fills an educational gap in the understanding of GCP at all levels. Written in concise language simple enough to be accessible to those new in the field, the dozens of real-life stories and detailed case studies at the end of each chapter make the book an invaluable resource for the more experienced, highlighting what can go wrong in a clinical study: A study of prostate cancer in the UK - An investigator brochure was not provided. The company argued that a brochure was unnecessary because the drug was already marketed. Indeed it was - for hypertension! A study of cardiovascular surgery in the UK - The consent dates were changed (by overwriting) to indicate that the patients had provided consent before the study started. The original dates post-dated the start of the study. A study of hypertension in Germany - The investigator brochure predated the study by nine years! Checklists are provided throughout the book to help monitors, auditors and investigators ensure that nothing important is overlooked. The authors present the topic of GCP with remarkable clarity, insight and enthusiasm emphasizing that this code of practice was not designed to make studies more difficult for investigators or more expensive for sponsors and CROs but, in the final analysis, to ensure the safety and well-being of study participants and future patients who will benefit from well-conducted, GCP-compliant studies.