Product Description
Originating as a one-day workshop sponsored by the Shriner’s Hospitals and the National Institutes of Health, Foot and Ankle Motion Analysis: Clinical Treatment and Technology provides a single source reference for the latest assessment technologies and their clinical applications. Presenting basic and advanced clinical applications in pediatric and adult cases, the book also introduces the technological advances themselves from a quantitative perspective. It describes novel approaches and emerging horizons related to mechanical paradigms, imaging, kinetics, robotics and simulation, tri-planar force sensing, and more. The book also includes a chapter of references and sources of support for future research and development prospects.
Product Details
* Amazon Sales Rank: #941479 in Books
* Published on: 2007-08-22
* Original language: English
* Number of items: 1
* Binding: Hardcover
* 704 pages
Showing posts with label Biological. Show all posts
Showing posts with label Biological. Show all posts
Monday, October 6, 2008
Tuesday, September 23, 2008
Harper’s Illustrated Biochemistry
Product Description
The most-up-to-date book on the market, gives readers the biochemistry background needed to succeed in medical school. Contains the latest case studies, discussions of biochemical diseases, clinical information, the fundamentals of biochemistry, and prevalent medical conditions. Concise and comprehensive, it is the perfect textbook for the USMLE review.
Product Details
* Amazon Sales Rank: #406284 in Books
* Published on: 2003-03-18
* Original language: English
* Number of items: 1
* Binding: Paperback
* 693 pages
Editorial Reviews
Review
"Originally published in 1939, this enduring reference/text continues with its mission to introduce biochemistry concepts to medical and health sciences students in concise text supported with graphs, charts, and diagrams. Updating the 2003 26th edition (which was drastically revised to make it shorter), the 27th includes substantial revisions as well as new coverage of bioinformatics and computational biology. Topics are each treated in about 10 pages and are presented under the themes of: structures and functions of proteins and enzymes; bioenergetics and the metabolism of carbohydrates and lipids; metabolism of proteins and amino acids; structure, function and replication of informational macromolecules; biochemistry of extracellular and intracellular communication; and special topics (e.g. nutrition, digestion and absorption, muscle and the cytoskeleton). The authors introduce each concept with discussion of its biomedical importance." (Sci-Tech Book News )
From the Back Cover
Currently the most up-to-date book on the market, Harper's Biochemistry, 25/e, gives you the biochemistry background you need to succeed in medical school. It contains the latest case studies, discussions of biochemical diseases, and clinical information. Concise but comprehensive, it is the perfect textbook for USMLE review. Features: covers the fundamentals of biochemistry in a relevant, interesting manner; contains information on prevalent medical conditions, including hypercholisterolemia, obesity, osteoporosis, and diabetes mellitus; covers new developments in metabolism and genetics, including the Human Genome Project and the genetic basis of hemochromatosis; presents hundreds of colorful images to help students visualize new information.
About the Author
Robert K. Murray, MD, PhD (University of Toronto, Ontario, Canada) Daryl K. Granner, MD (Vanderbilt University, Nashville, Tennessee) Peter A. Mayes, PhD, DSc (University of London, London, England) Victor W. Rodwell, PhD (Purdue University, West Lafayette, Indiana)
Customer Reviews
Biochemistry for Dummies2
I am a medical school professor and am familiar with the different biochemistry textbooks. Harper's is a simplified text book that does not have the detail of depth of information one finds in the gold-standard texts of Lehninger or Stryer. There is a reason why these texts and not Harper's are much more commonly found in the undergraduate, graduate and medical school classrooms. Harper's is ok for the educated layperson or for the non-biologist who wants an overview of biochemistry.
Complicated3
I'm a second year med student and this is the most difficult book I have to read. No so much because of the difficulty of the subject but cause it's written in so complicated way. Also to fully understand the contents I think one must have somewhat biochemical background. Which alot of people don't have. I find myself reading more from wikipeadia then from the book!
great for review5
While this book may not give quite the same level of detail found in some of the more massive and expensive intro to biochem texts, it is nevertheless a valuable reference. The fundamentals are all here, in an admirably clear and concise form. That makes going back to review much easier than with the fat books. In that way, this book fills an important gap in the field of available texts. If however one comes across a particularly difficult concept, the concise explanations may leave them wanting or needing more. In fairness though, I think a lot of the fatter books have the same drawback despite their longwindedness. Afterall, biochemistry can be pretty tough no matter what book you're looking at. If you are using the book as part of a class, then theoretically that is why there is an instructor, lectures and tutorial sessions. Admittedly, and to the student's detriment, the system doesn't always work out that way. I've found the book to be excellent for review because of its brevity and clarity. This book also gets high marks for attempting to point out the clinical relevance of the material, something that cannot be said for the majority of the big textbooks.
The most-up-to-date book on the market, gives readers the biochemistry background needed to succeed in medical school. Contains the latest case studies, discussions of biochemical diseases, clinical information, the fundamentals of biochemistry, and prevalent medical conditions. Concise and comprehensive, it is the perfect textbook for the USMLE review.
Product Details
* Amazon Sales Rank: #406284 in Books
* Published on: 2003-03-18
* Original language: English
* Number of items: 1
* Binding: Paperback
* 693 pages
Editorial Reviews
Review
"Originally published in 1939, this enduring reference/text continues with its mission to introduce biochemistry concepts to medical and health sciences students in concise text supported with graphs, charts, and diagrams. Updating the 2003 26th edition (which was drastically revised to make it shorter), the 27th includes substantial revisions as well as new coverage of bioinformatics and computational biology. Topics are each treated in about 10 pages and are presented under the themes of: structures and functions of proteins and enzymes; bioenergetics and the metabolism of carbohydrates and lipids; metabolism of proteins and amino acids; structure, function and replication of informational macromolecules; biochemistry of extracellular and intracellular communication; and special topics (e.g. nutrition, digestion and absorption, muscle and the cytoskeleton). The authors introduce each concept with discussion of its biomedical importance." (Sci-Tech Book News )
From the Back Cover
Currently the most up-to-date book on the market, Harper's Biochemistry, 25/e, gives you the biochemistry background you need to succeed in medical school. It contains the latest case studies, discussions of biochemical diseases, and clinical information. Concise but comprehensive, it is the perfect textbook for USMLE review. Features: covers the fundamentals of biochemistry in a relevant, interesting manner; contains information on prevalent medical conditions, including hypercholisterolemia, obesity, osteoporosis, and diabetes mellitus; covers new developments in metabolism and genetics, including the Human Genome Project and the genetic basis of hemochromatosis; presents hundreds of colorful images to help students visualize new information.
About the Author
Robert K. Murray, MD, PhD (University of Toronto, Ontario, Canada) Daryl K. Granner, MD (Vanderbilt University, Nashville, Tennessee) Peter A. Mayes, PhD, DSc (University of London, London, England) Victor W. Rodwell, PhD (Purdue University, West Lafayette, Indiana)
Customer Reviews
Biochemistry for Dummies2
I am a medical school professor and am familiar with the different biochemistry textbooks. Harper's is a simplified text book that does not have the detail of depth of information one finds in the gold-standard texts of Lehninger or Stryer. There is a reason why these texts and not Harper's are much more commonly found in the undergraduate, graduate and medical school classrooms. Harper's is ok for the educated layperson or for the non-biologist who wants an overview of biochemistry.
Complicated3
I'm a second year med student and this is the most difficult book I have to read. No so much because of the difficulty of the subject but cause it's written in so complicated way. Also to fully understand the contents I think one must have somewhat biochemical background. Which alot of people don't have. I find myself reading more from wikipeadia then from the book!
great for review5
While this book may not give quite the same level of detail found in some of the more massive and expensive intro to biochem texts, it is nevertheless a valuable reference. The fundamentals are all here, in an admirably clear and concise form. That makes going back to review much easier than with the fat books. In that way, this book fills an important gap in the field of available texts. If however one comes across a particularly difficult concept, the concise explanations may leave them wanting or needing more. In fairness though, I think a lot of the fatter books have the same drawback despite their longwindedness. Afterall, biochemistry can be pretty tough no matter what book you're looking at. If you are using the book as part of a class, then theoretically that is why there is an instructor, lectures and tutorial sessions. Admittedly, and to the student's detriment, the system doesn't always work out that way. I've found the book to be excellent for review because of its brevity and clarity. This book also gets high marks for attempting to point out the clinical relevance of the material, something that cannot be said for the majority of the big textbooks.
Laboratory Exercises in Microbiology
Product Description
"The best feature of this lab manual is its style and organization. It is not just readable, it is thorough.... It is comparable to the best lab manuals I have used or read."
—William Coleman, University of Hartford
"It is a friendly-to-student book and I think student users will appreciate it--even if they don't realize why. I think they will like microbiology just a bit more."
—Loyd J. Hays, University of Texas at San Antonio
Clear, concise, and always engaging!
Written specifically for allied health students, Pollack, Findlay, Mondschein, and Modesto’s Laboratory Exercises in Microbiology, 2/e focuses on what students need to succeed in the lab: clear, concise, and highly engaging exercises and activities, rather than content that is simply adapted from a standard microbiology textbook.
Throughout the manual, a variety of interactive activities and experiments convey the basic concepts of microbiology––all in a student-friendly tone. Students also have the opportunity to explore methods that allow the safe movement or transfer of microbial cells from one type of growth environment to another, classification and identification of microbes, microbial biochemistry, as well as laboratory exercises from medical, food, and environmental microbiology.
Product Details
* Amazon Sales Rank: #483700 in Books
* Published on: 2004-10-25
* Original language: English
* Number of items: 1
* Binding: Spiral-bound
* 280 pages
Editorial Reviews
From the Back Cover
"The best feature of this lab manual is its style and organization. It is not just readable, it is thorough.... It is comparable to the best lab manuals I have used or read."
—William Coleman, University of Hartford
"It is a friendly-to-student book and I think student users will appreciate it--even if they don't realize why. I think they will like microbiology just a bit more."
—Loyd J. Hays, University of Texas at San Antonio
Clear, concise, and always engaging!
Written specifically for allied health students, Pollack, Findlay, Mondschein, and Modesto’s Laboratory Exercises in Microbiology, 2/e focuses on what students need to succeed in the lab: clear, concise, and highly engaging exercises and activities, rather than content that is simply adapted from a standard microbiology textbook.
Throughout the manual, a variety of interactive activities and experiments convey the basic concepts of microbiology––all in a student-friendly tone. Students also have the opportunity to explore methods that allow the safe movement or transfer of microbial cells from one type of growth environment to another, classification and identification of microbes, microbial biochemistry, as well as laboratory exercises from medical, food, and environmental microbiology.
For additional student and instructor resources, go to
www.wiley.com/college/pollack
Also available Winter 2004-2005:
Microbiology: Principles and Explorations, 6e by Jacquelyn G. Black
www.wiley.com/college/black
"The best feature of this lab manual is its style and organization. It is not just readable, it is thorough.... It is comparable to the best lab manuals I have used or read."
—William Coleman, University of Hartford
"It is a friendly-to-student book and I think student users will appreciate it--even if they don't realize why. I think they will like microbiology just a bit more."
—Loyd J. Hays, University of Texas at San Antonio
Clear, concise, and always engaging!
Written specifically for allied health students, Pollack, Findlay, Mondschein, and Modesto’s Laboratory Exercises in Microbiology, 2/e focuses on what students need to succeed in the lab: clear, concise, and highly engaging exercises and activities, rather than content that is simply adapted from a standard microbiology textbook.
Throughout the manual, a variety of interactive activities and experiments convey the basic concepts of microbiology––all in a student-friendly tone. Students also have the opportunity to explore methods that allow the safe movement or transfer of microbial cells from one type of growth environment to another, classification and identification of microbes, microbial biochemistry, as well as laboratory exercises from medical, food, and environmental microbiology.
Product Details
* Amazon Sales Rank: #483700 in Books
* Published on: 2004-10-25
* Original language: English
* Number of items: 1
* Binding: Spiral-bound
* 280 pages
Editorial Reviews
From the Back Cover
"The best feature of this lab manual is its style and organization. It is not just readable, it is thorough.... It is comparable to the best lab manuals I have used or read."
—William Coleman, University of Hartford
"It is a friendly-to-student book and I think student users will appreciate it--even if they don't realize why. I think they will like microbiology just a bit more."
—Loyd J. Hays, University of Texas at San Antonio
Clear, concise, and always engaging!
Written specifically for allied health students, Pollack, Findlay, Mondschein, and Modesto’s Laboratory Exercises in Microbiology, 2/e focuses on what students need to succeed in the lab: clear, concise, and highly engaging exercises and activities, rather than content that is simply adapted from a standard microbiology textbook.
Throughout the manual, a variety of interactive activities and experiments convey the basic concepts of microbiology––all in a student-friendly tone. Students also have the opportunity to explore methods that allow the safe movement or transfer of microbial cells from one type of growth environment to another, classification and identification of microbes, microbial biochemistry, as well as laboratory exercises from medical, food, and environmental microbiology.
For additional student and instructor resources, go to
www.wiley.com/college/pollack
Also available Winter 2004-2005:
Microbiology: Principles and Explorations, 6e by Jacquelyn G. Black
www.wiley.com/college/black
Toxicological Chemistry and Biochemistry, Third Editionb
Product Description
This unique book bridges the gap between toxicology and chemistry at a level understandable by a wide spectrum of readers with various interests and a broad range of backgrounds in chemistry, biochemistry, and toxicology. The third edition has been thoroughly updated and expanded to reflect recent advances in important areas of research, including toxicogenetics and toxic effects on various body systems. Toxicological Chemistry and Biochemistry, Third Edition begins by outlining the basic concepts of general chemistry, organic chemistry, and biochemistry needed to understand the topics in the book. The author then presents an overview of environmental chemistry so that you can understand the remainder of the material covered within that framework. He also discusses biodegradation, bioaccumulation, and biochemical processes that occur in water and soil. The new chapter on toxic effects considers toxicities to the endocrine and reproductive systems, and the section on xenobiotics analysis deals with the determination of toxicants and their metabolites in blood and other biological materials. The chapter on the genetic aspects of toxicology discusses the ways in which chemical damage to DNA can cause mutations, cancer, and other toxic effects on specific body systems, and it considers the role of genetics in determining individual susceptibilities to various toxicants. Toxicological Chemistry and Biochemistry, Third Edition retains the basic information and structure that made the first two editions popular with students and industry professionals, while enhancing the usefulness of the book and modernizing it in important areas. Review questions and supplementary references at the end of each chapter round out the third edition of this bestselling work.
Product Details
* Amazon Sales Rank: #960561 in Books
* Published on: 2002-09-25
* Original language: English
* Number of items: 1
* Binding: Hardcover
* 425 pages
Customer Reviews
This textbook captures the essentials of its title.5
Compared to other text books of this nature dealing with the same scientific discipline, Manahan captures the reader's attention by dealing with several environmental focal points from and organic, toxicological, and environmental chemistry standpoint.
Based on its uniqueness and seemingly open paths for comprehension, this textbook is a must for those desiring further knowledge in the area of toxicological chemistry with a detailed spectrum of organic and environmental chemistry with a keen mix of environmental toxicology.
In short one would soon surmise this textbook is nothing short of academically remarkable and a credit to the fields of environmental toxicology, organic chemistry, and environmental chemistry. It is a must read science text for those in the environmental and chemistry fields whether academic, industrial, or government.
This textbook captures the essentials of its title.5
Compared to other text books of this nature dealing with the same scientific discipline, Manahan captures the reader's attention by dealing with several environmental focal points from and organic, toxicological, and environmental chemistry standpoint.
Based on its uniqueness and seemingly open paths for comprehension, this textbook is a must for those desiring further knowledge in the area of toxicological chemistry with a detailed spectrum of organic and environmental chemistry with a keen mix of environmental toxicology.
In short one would soon surmise this textbook is nothing short of academically remarkable and a credit to the fields of environmental toxicology, organic chemistry, and environmental chemistry. It is a must read science text for those in the environmental and chemistry fields whether academic, industrial, or government.
This unique book bridges the gap between toxicology and chemistry at a level understandable by a wide spectrum of readers with various interests and a broad range of backgrounds in chemistry, biochemistry, and toxicology. The third edition has been thoroughly updated and expanded to reflect recent advances in important areas of research, including toxicogenetics and toxic effects on various body systems. Toxicological Chemistry and Biochemistry, Third Edition begins by outlining the basic concepts of general chemistry, organic chemistry, and biochemistry needed to understand the topics in the book. The author then presents an overview of environmental chemistry so that you can understand the remainder of the material covered within that framework. He also discusses biodegradation, bioaccumulation, and biochemical processes that occur in water and soil. The new chapter on toxic effects considers toxicities to the endocrine and reproductive systems, and the section on xenobiotics analysis deals with the determination of toxicants and their metabolites in blood and other biological materials. The chapter on the genetic aspects of toxicology discusses the ways in which chemical damage to DNA can cause mutations, cancer, and other toxic effects on specific body systems, and it considers the role of genetics in determining individual susceptibilities to various toxicants. Toxicological Chemistry and Biochemistry, Third Edition retains the basic information and structure that made the first two editions popular with students and industry professionals, while enhancing the usefulness of the book and modernizing it in important areas. Review questions and supplementary references at the end of each chapter round out the third edition of this bestselling work.
Product Details
* Amazon Sales Rank: #960561 in Books
* Published on: 2002-09-25
* Original language: English
* Number of items: 1
* Binding: Hardcover
* 425 pages
Customer Reviews
This textbook captures the essentials of its title.5
Compared to other text books of this nature dealing with the same scientific discipline, Manahan captures the reader's attention by dealing with several environmental focal points from and organic, toxicological, and environmental chemistry standpoint.
Based on its uniqueness and seemingly open paths for comprehension, this textbook is a must for those desiring further knowledge in the area of toxicological chemistry with a detailed spectrum of organic and environmental chemistry with a keen mix of environmental toxicology.
In short one would soon surmise this textbook is nothing short of academically remarkable and a credit to the fields of environmental toxicology, organic chemistry, and environmental chemistry. It is a must read science text for those in the environmental and chemistry fields whether academic, industrial, or government.
This textbook captures the essentials of its title.5
Compared to other text books of this nature dealing with the same scientific discipline, Manahan captures the reader's attention by dealing with several environmental focal points from and organic, toxicological, and environmental chemistry standpoint.
Based on its uniqueness and seemingly open paths for comprehension, this textbook is a must for those desiring further knowledge in the area of toxicological chemistry with a detailed spectrum of organic and environmental chemistry with a keen mix of environmental toxicology.
In short one would soon surmise this textbook is nothing short of academically remarkable and a credit to the fields of environmental toxicology, organic chemistry, and environmental chemistry. It is a must read science text for those in the environmental and chemistry fields whether academic, industrial, or government.
Biopharmaceuticals: Biochemistry and Biotechnology
Product Description
The latest edition of this highly acclaimed textbook, provides a comprehensive and up-to-date overview of the science and medical applications of biopharmaceutical products. Biopharmaceuticals refers to pharmaceutical substances derived from biological sources, and increasingly, it is synonymous with 'newer' pharmaceutical substances derived from genetic engineering or hybridoma technology.
This superbly written review of the important areas of investigation in the field, covers drug production, plus the biochemical and molecular mechanisms of action together with the biotechnology of major biopharmaceutical types on the market or currently under development. There is also additional material reflecting both the technical advances in the area and detailed information on key topics such as the influence of genomics on drug discovery.
Product Details
* Amazon Sales Rank: #912724 in Books
* Published on: 2003-09-19
* Original language: English
* Number of items: 1
* Binding: Paperback
* 570 pages
Editorial Reviews
Review
"…contains just about everything that anyone would want to know about the subject…It's all here in this easy-to-read textbook.” (Biochemistry and Molecular Education, March/April 2004)
"...well written… (and) copiously illustrated..." (Chemistry & Industry, 17th January 2005)
“This book should be recommended reading for all under-graduate course in pharmacy and the pharmaceutical sciences …”. (Cell Biochemistry & Function, March-April 2005)
Review
"…contains just about everything that anyone would want to know about the subject…It's all here in this easy-to-read textbook.” (Biochemistry and Molecular Education, March/April 2004)
"...well written… (and) copiously illustrated..." (Chemistry & Industry, 17th January 2005)
“This book should be recommended reading for all under-graduate course in pharmacy and the pharmaceutical sciences …”. (Cell Biochemistry & Function, March-April 2005)
From the Back Cover
Biopharmaceuticals: Biochemistry and Biotechnology, Second Edition, provides a comprehensive, up-to-date overview of the science and medical applications of biopharmaceutical products.
Extensively revised and updated, the Second Edition of this highly successful textbook discusses the latest developments in the field, providing a greater focus on actual commercial products and how they are manufactured. Substantial new sections on detailing biopharmaceutical drug delivery and how advances in genomics and proteomics will impact upon (bio)pharmaceutical drug development are also included.
* Provides a balanced overview of the biopharmaceutical industry, including material on key developments in the field.
* Each chapter supplemented with an extensive further reading section
* Aimed at students taking courses in biotechnology, pharmaceutical science, biochemistry, microbiology or medicine
* An ideal reference for those already employed in the (bio)pharmaceutical sector wishing to gain a better overview of the industry.
Reviews of Biopharmace u ticals:
"Biopharmaceuticals: Biochemistry and Biotechnology contain(s) some very useful information and ultimately serves as a comprehensive introduction to both the biopharmaceutical industry and its role within the larger arena of pharmaceuticals. For those new to, or keen to be involved with biopharmaceuticals, the book will undoubtedly provide a solid grounding of not just the technology, but of the industry as a whole."
—Pharmaceutical Technology Europe
"This great compliment of scientific literature, is easy-to-read and understand, up-to-date as well as comprehensive."
—Bioseparation
"Biopharmaceuticals…is well written and provides an excellent overview of the biotechnology industry…. This book is an excellent and balanced source of information about the biotechnology industry."
—FEBS Letters
The latest edition of this highly acclaimed textbook, provides a comprehensive and up-to-date overview of the science and medical applications of biopharmaceutical products. Biopharmaceuticals refers to pharmaceutical substances derived from biological sources, and increasingly, it is synonymous with 'newer' pharmaceutical substances derived from genetic engineering or hybridoma technology.
This superbly written review of the important areas of investigation in the field, covers drug production, plus the biochemical and molecular mechanisms of action together with the biotechnology of major biopharmaceutical types on the market or currently under development. There is also additional material reflecting both the technical advances in the area and detailed information on key topics such as the influence of genomics on drug discovery.
Product Details
* Amazon Sales Rank: #912724 in Books
* Published on: 2003-09-19
* Original language: English
* Number of items: 1
* Binding: Paperback
* 570 pages
Editorial Reviews
Review
"…contains just about everything that anyone would want to know about the subject…It's all here in this easy-to-read textbook.” (Biochemistry and Molecular Education, March/April 2004)
"...well written… (and) copiously illustrated..." (Chemistry & Industry, 17th January 2005)
“This book should be recommended reading for all under-graduate course in pharmacy and the pharmaceutical sciences …”. (Cell Biochemistry & Function, March-April 2005)
Review
"…contains just about everything that anyone would want to know about the subject…It's all here in this easy-to-read textbook.” (Biochemistry and Molecular Education, March/April 2004)
"...well written… (and) copiously illustrated..." (Chemistry & Industry, 17th January 2005)
“This book should be recommended reading for all under-graduate course in pharmacy and the pharmaceutical sciences …”. (Cell Biochemistry & Function, March-April 2005)
From the Back Cover
Biopharmaceuticals: Biochemistry and Biotechnology, Second Edition, provides a comprehensive, up-to-date overview of the science and medical applications of biopharmaceutical products.
Extensively revised and updated, the Second Edition of this highly successful textbook discusses the latest developments in the field, providing a greater focus on actual commercial products and how they are manufactured. Substantial new sections on detailing biopharmaceutical drug delivery and how advances in genomics and proteomics will impact upon (bio)pharmaceutical drug development are also included.
* Provides a balanced overview of the biopharmaceutical industry, including material on key developments in the field.
* Each chapter supplemented with an extensive further reading section
* Aimed at students taking courses in biotechnology, pharmaceutical science, biochemistry, microbiology or medicine
* An ideal reference for those already employed in the (bio)pharmaceutical sector wishing to gain a better overview of the industry.
Reviews of Biopharmace u ticals:
"Biopharmaceuticals: Biochemistry and Biotechnology contain(s) some very useful information and ultimately serves as a comprehensive introduction to both the biopharmaceutical industry and its role within the larger arena of pharmaceuticals. For those new to, or keen to be involved with biopharmaceuticals, the book will undoubtedly provide a solid grounding of not just the technology, but of the industry as a whole."
—Pharmaceutical Technology Europe
"This great compliment of scientific literature, is easy-to-read and understand, up-to-date as well as comprehensive."
—Bioseparation
"Biopharmaceuticals…is well written and provides an excellent overview of the biotechnology industry…. This book is an excellent and balanced source of information about the biotechnology industry."
—FEBS Letters
The Oncogenomics Handbook
Product Description
An integrated overview of cancer drug discovery and development from the bench to the clinic, showing with broad strokes and representative examples the drug development process as a network of linked components leading from the discovered target to the ultimate therapeutic product. Following a systems biology approach, the authors explain genomic databases and how to discover oncological targets from them, how then to advance from the gene and transcript to the level of protein biochemistry, how next to move from the chemical realm to that of the living cell and, ultimately, pursue animal modeling and clinical development. Emerging cancer therapeutics including Ritux an, Erbitux, Gleevec Herceptin, Avastin, ABX-EGF, Velcade, Kepivance, Iressa, Tarceva, and Zevalin are addressed. Highlights include cancer genomics, pharmacogenomics, transcriptomics, gene expression analysis, proteomic and enzymatic cancer profiling technologies, and cellular and animal approaches to cancer target validation.
Product Details
* Amazon Sales Rank: #2410378 in Books
* Published on: 2005-04-15
* Original language: English
* Number of items: 1
* Binding: Hardcover
* 768 pages
Editorial Reviews
Review
"...an excellent resource to anyone interested in the field of cancer or cancer research. Its comprehensive overview of different perspectives in oncologic genomics will certainly be beneficial to a wide range of professionals in their ultimate endeavors towards further development of advanced cancer therapies." - Doody's Health Sciences and Book Review Journal
"...provides an integrated overview of cancer drug discovery and development...." - BioTech International
Customer Reviews
Thorough Review of Genomics-Based Cancer Research5
This work draws on the experience of dozens of leading scientists in the public and private sector in their efforts to use information from genomics to understand and develop cancer therapies. A wide variety of experimental cancer drugs are discussed, and clinical trial data are presented. At 750 pages it is a substantial work, with enough technical detail to suit the bench scientist and physician, yet an easy enough read to be appreciated by the avid learner.
An integrated overview of cancer drug discovery and development from the bench to the clinic, showing with broad strokes and representative examples the drug development process as a network of linked components leading from the discovered target to the ultimate therapeutic product. Following a systems biology approach, the authors explain genomic databases and how to discover oncological targets from them, how then to advance from the gene and transcript to the level of protein biochemistry, how next to move from the chemical realm to that of the living cell and, ultimately, pursue animal modeling and clinical development. Emerging cancer therapeutics including Ritux an, Erbitux, Gleevec Herceptin, Avastin, ABX-EGF, Velcade, Kepivance, Iressa, Tarceva, and Zevalin are addressed. Highlights include cancer genomics, pharmacogenomics, transcriptomics, gene expression analysis, proteomic and enzymatic cancer profiling technologies, and cellular and animal approaches to cancer target validation.
Product Details
* Amazon Sales Rank: #2410378 in Books
* Published on: 2005-04-15
* Original language: English
* Number of items: 1
* Binding: Hardcover
* 768 pages
Editorial Reviews
Review
"...an excellent resource to anyone interested in the field of cancer or cancer research. Its comprehensive overview of different perspectives in oncologic genomics will certainly be beneficial to a wide range of professionals in their ultimate endeavors towards further development of advanced cancer therapies." - Doody's Health Sciences and Book Review Journal
"...provides an integrated overview of cancer drug discovery and development...." - BioTech International
Customer Reviews
Thorough Review of Genomics-Based Cancer Research5
This work draws on the experience of dozens of leading scientists in the public and private sector in their efforts to use information from genomics to understand and develop cancer therapies. A wide variety of experimental cancer drugs are discussed, and clinical trial data are presented. At 750 pages it is a substantial work, with enough technical detail to suit the bench scientist and physician, yet an easy enough read to be appreciated by the avid learner.
Monday, September 22, 2008
Mathematical Physiology
Product Description
Mathematical Physiology provides an introduction into physiology using the tools and perspectives of mathematical modeling and analysis. It describes ways in which mathematical theory may be used to give insights into physiological questions and how physiological questions can in turn lead to new mathematical problems.
The book is divided in two parts, the first dealing with the fundamental principles of cell physiology, and the second with the physiology of systems. In the first part, after an introduction to basic biochemistry and enzyme reactions, the authors discuss volume control, the membrane potential, ionic flow through channels, excitability, calcium dynamics, and electrical bursting. This first part concludes with spatial aspects such as synaptic transmission, gap junctions, the linear cable equation, nonlinear wave propagation in neurons, and calcium waves. In the second part, the human body is studied piece by piece, beginning with an introduction to electrocardiology, followed by the physiology of the circulatory system, blood muscle, hormones, and kindeys. Finally, the authors examine the digestive system and the visual system, ending with the inner ear. This book will be of interest to researchers, to graduate students and advanced undergraduate students in applied mathematics who wish to learn how to build and analyze mathematical models and become familiar with new areas of applications, as well as to physiologists interested in learning about theoretical approaches to their work.
Mathematical Reviews, 2000: "This is neither a physiology book nor a mathematics book, but it is probably the best book ever written on the interdisciplinary field of mathematical physiology, i.e. mathematics applied to modelling physiological phenomena. The book is highly recommended to anybody interested in mathematical or theoretical physiology."
Product Details
* Amazon Sales Rank: #464380 in Books
* Published on: 2001-05-11
* Original language: English
* Number of items: 1
* Binding: Hardcover
* 792 pages
Editorial Reviews
Review
"...skillfully written...an excellent job of pulling together detailed, up-to-date results from a vast literature on mathematical physiology..." -- IEEE Control Systems Magazine
From the reviews:
"Probably the best book ever written on the subject of mathematical physiology … It contains numerous exercises, enough to keep even the most diligent student busy, and a comprehensive list of approximately 600 references … highly recommended to anybody interested in mathematical or theoretical physiology." Mathematical Reviews
"In addition to being good reading, excellent pedagogy, and appealing science, the exposition is lucid and clear, and there are many good problem sets to choose from … Highly recommended." Journal of the Society of Mathematical Biology
Customer Reviews
Poor explanations2
I used this book in a graduate school course. I found myself checking out other mathematical physiology books to understand what they were talking about. There's poor explanations, and they skip certain steps that would help the reader get a better understanding of what's going on. Save your money and skip this book.
this is the book about systems biology!!!5
If you would like to delve into the true complexity of systems biology (physiology), get this book. It's even much better than computational cell biology book by JJ Tyson et al since it's described in depth. But I'd rephrase Tyson's comment: "The regulatory system is so complex that it defies understanding by verbal arguments alone."
All of it fascinating....5
This book is an excellent overview of the major research into the mathematics of physiological processes. The first part of the book covers cellular physiology beginning with a discussion of biochemical reactions in the first chapter. Some of the applications of dynamical systems are nicely illustrated here, especially bifurcation theory.
Applications of the diffusion equation follow in the next chapter on cellular homeostasis. The Nernst-Planck electrodiffusion equation is discussed but not derived, and is solved in the constant field approximation.
This is complicated somewthat in the next chapter on membrane ion channels, where the potential across the membrane is not assumed to have a constant gradient. There is a discussion of channel blocking drugs in the last section, but unfortunately it is too short. This is an important area of application, with the experimental validation of the mathematical results of upmost importance.
The Hodgkin-Huxley and the FitzHugh-Nagumo equations dominate the next chapter on electrical signaling in cells. The phase space analysis of these models is discussed, along with an interesting treatment of the excitability of cardiac cells in the Appendix of the chapter.
A very well-written treatment, along with helpful diagrams, of calcium dynamics is given in Chapter 5. The authors show how ignoring the fast variables and transients lead one to a solution of they dynamical problem of the receptor model.
Phase space analysis is used extensively in the next chapter on electrical bursting, with emphasis on bursting in pancreatic beta-cells. An interesting discussion on the classification of bursting oscillations is given purely in terms of bifurcation theory.
That synaptic transimission is quantal in nature is one of the topics of the next chapter on intercellular communication. This is the first time in the book that probabilistic methods are introduced into the modeling. The authors quote some very old references on the experimental verification of the quantal model, leaving the reader wondering if more modern experiments have been done. In calculating the effective diffusion coefficients, the authors introduce the technique of homogenization, and give a explanation of the rationale behind the technique. The strategy of determining the behavior at a particular scale without solving completely the details at a finer scale is one that has proven to be quite productive, especially in physics.
The use of partial differential equations is increased in the next chapter on electrical flow in neurons, with the linear cable equation playing the dominant role. The authors use transform methods to obtain the solutions in the main text and exercises, giving references for the reader not familiar with these techniques.
The nonlinear cable equation is the subject of the next chapter, with traveling waves solutions of the bistable equation given the main emphasis. Shooting methods are employed in the solution of this equation, and the authors also treat the more difficult case of the discrete bistable equation.
Wave propagation in higher dimensions is the subject of the next chapter, with spiral waves discussed along with a brief discussion of scroll waves.
The fascinating subject of cardiac propagation is the subject of Chapter 11. The mathematical techniques are not much more complicated, but mathematicians coming to cardiac biology for the first time will need to pay attention to the details. One of the most interesting subjects of the book is treated in Chapter 13 on cell function regulation. Mathematical models of the G1 and G2 checkpoint processes are given.
Part two of the book emphasizes the mathematical modeling of the biological systems, rather than at the cellular level. This part begins with a consideration of how cellular activity can be coordinated to produce a regular heartbeat and how failure can occur. Interestingly, a Schrodinger-like equation appears when linearizing the FitzHugh-Nagumo equations for oscillating cells. And, interestingly, dynamical systems via circle maps appear in the model of the AV modal signal. This is followed by a lengthy and fascinating discussion of the mathematics of the circulatory system. Unfortunately, the discussion on the dangers of high blood pressure is not justified by any mathematical models in the book. It would have been very interesting to see a model developed that would predict the effects of hypertension on the heart, kidneys, etc and one that would be compared with historical and clinical data.
The next chapters discuss physiology of the blood, respiration, and muscles. A very interesting discussion of hormone physiology and mammal ovulation is given. The mathematical models of the kidneys and gastrointestinal systems are very detailed and very enlightening for individuals not in these fields.
The book ends with chapters on the physiology of sight and hearing. The discussion of the light reflex mechanism is very interesting as the authors use linear stability analysis. The oscillations of the basilar membrane in the inner ear are good reading for the physicist.
This book would be of great interest to mathematicians who are entering the field of computational physiology or computational biologists who need an understanding of the modeling required. Very captivating reading........
Mathematical Physiology provides an introduction into physiology using the tools and perspectives of mathematical modeling and analysis. It describes ways in which mathematical theory may be used to give insights into physiological questions and how physiological questions can in turn lead to new mathematical problems.
The book is divided in two parts, the first dealing with the fundamental principles of cell physiology, and the second with the physiology of systems. In the first part, after an introduction to basic biochemistry and enzyme reactions, the authors discuss volume control, the membrane potential, ionic flow through channels, excitability, calcium dynamics, and electrical bursting. This first part concludes with spatial aspects such as synaptic transmission, gap junctions, the linear cable equation, nonlinear wave propagation in neurons, and calcium waves. In the second part, the human body is studied piece by piece, beginning with an introduction to electrocardiology, followed by the physiology of the circulatory system, blood muscle, hormones, and kindeys. Finally, the authors examine the digestive system and the visual system, ending with the inner ear. This book will be of interest to researchers, to graduate students and advanced undergraduate students in applied mathematics who wish to learn how to build and analyze mathematical models and become familiar with new areas of applications, as well as to physiologists interested in learning about theoretical approaches to their work.
Mathematical Reviews, 2000: "This is neither a physiology book nor a mathematics book, but it is probably the best book ever written on the interdisciplinary field of mathematical physiology, i.e. mathematics applied to modelling physiological phenomena. The book is highly recommended to anybody interested in mathematical or theoretical physiology."
Product Details
* Amazon Sales Rank: #464380 in Books
* Published on: 2001-05-11
* Original language: English
* Number of items: 1
* Binding: Hardcover
* 792 pages
Editorial Reviews
Review
"...skillfully written...an excellent job of pulling together detailed, up-to-date results from a vast literature on mathematical physiology..." -- IEEE Control Systems Magazine
From the reviews:
"Probably the best book ever written on the subject of mathematical physiology … It contains numerous exercises, enough to keep even the most diligent student busy, and a comprehensive list of approximately 600 references … highly recommended to anybody interested in mathematical or theoretical physiology." Mathematical Reviews
"In addition to being good reading, excellent pedagogy, and appealing science, the exposition is lucid and clear, and there are many good problem sets to choose from … Highly recommended." Journal of the Society of Mathematical Biology
Customer Reviews
Poor explanations2
I used this book in a graduate school course. I found myself checking out other mathematical physiology books to understand what they were talking about. There's poor explanations, and they skip certain steps that would help the reader get a better understanding of what's going on. Save your money and skip this book.
this is the book about systems biology!!!5
If you would like to delve into the true complexity of systems biology (physiology), get this book. It's even much better than computational cell biology book by JJ Tyson et al since it's described in depth. But I'd rephrase Tyson's comment: "The regulatory system is so complex that it defies understanding by verbal arguments alone."
All of it fascinating....5
This book is an excellent overview of the major research into the mathematics of physiological processes. The first part of the book covers cellular physiology beginning with a discussion of biochemical reactions in the first chapter. Some of the applications of dynamical systems are nicely illustrated here, especially bifurcation theory.
Applications of the diffusion equation follow in the next chapter on cellular homeostasis. The Nernst-Planck electrodiffusion equation is discussed but not derived, and is solved in the constant field approximation.
This is complicated somewthat in the next chapter on membrane ion channels, where the potential across the membrane is not assumed to have a constant gradient. There is a discussion of channel blocking drugs in the last section, but unfortunately it is too short. This is an important area of application, with the experimental validation of the mathematical results of upmost importance.
The Hodgkin-Huxley and the FitzHugh-Nagumo equations dominate the next chapter on electrical signaling in cells. The phase space analysis of these models is discussed, along with an interesting treatment of the excitability of cardiac cells in the Appendix of the chapter.
A very well-written treatment, along with helpful diagrams, of calcium dynamics is given in Chapter 5. The authors show how ignoring the fast variables and transients lead one to a solution of they dynamical problem of the receptor model.
Phase space analysis is used extensively in the next chapter on electrical bursting, with emphasis on bursting in pancreatic beta-cells. An interesting discussion on the classification of bursting oscillations is given purely in terms of bifurcation theory.
That synaptic transimission is quantal in nature is one of the topics of the next chapter on intercellular communication. This is the first time in the book that probabilistic methods are introduced into the modeling. The authors quote some very old references on the experimental verification of the quantal model, leaving the reader wondering if more modern experiments have been done. In calculating the effective diffusion coefficients, the authors introduce the technique of homogenization, and give a explanation of the rationale behind the technique. The strategy of determining the behavior at a particular scale without solving completely the details at a finer scale is one that has proven to be quite productive, especially in physics.
The use of partial differential equations is increased in the next chapter on electrical flow in neurons, with the linear cable equation playing the dominant role. The authors use transform methods to obtain the solutions in the main text and exercises, giving references for the reader not familiar with these techniques.
The nonlinear cable equation is the subject of the next chapter, with traveling waves solutions of the bistable equation given the main emphasis. Shooting methods are employed in the solution of this equation, and the authors also treat the more difficult case of the discrete bistable equation.
Wave propagation in higher dimensions is the subject of the next chapter, with spiral waves discussed along with a brief discussion of scroll waves.
The fascinating subject of cardiac propagation is the subject of Chapter 11. The mathematical techniques are not much more complicated, but mathematicians coming to cardiac biology for the first time will need to pay attention to the details. One of the most interesting subjects of the book is treated in Chapter 13 on cell function regulation. Mathematical models of the G1 and G2 checkpoint processes are given.
Part two of the book emphasizes the mathematical modeling of the biological systems, rather than at the cellular level. This part begins with a consideration of how cellular activity can be coordinated to produce a regular heartbeat and how failure can occur. Interestingly, a Schrodinger-like equation appears when linearizing the FitzHugh-Nagumo equations for oscillating cells. And, interestingly, dynamical systems via circle maps appear in the model of the AV modal signal. This is followed by a lengthy and fascinating discussion of the mathematics of the circulatory system. Unfortunately, the discussion on the dangers of high blood pressure is not justified by any mathematical models in the book. It would have been very interesting to see a model developed that would predict the effects of hypertension on the heart, kidneys, etc and one that would be compared with historical and clinical data.
The next chapters discuss physiology of the blood, respiration, and muscles. A very interesting discussion of hormone physiology and mammal ovulation is given. The mathematical models of the kidneys and gastrointestinal systems are very detailed and very enlightening for individuals not in these fields.
The book ends with chapters on the physiology of sight and hearing. The discussion of the light reflex mechanism is very interesting as the authors use linear stability analysis. The oscillations of the basilar membrane in the inner ear are good reading for the physicist.
This book would be of great interest to mathematicians who are entering the field of computational physiology or computational biologists who need an understanding of the modeling required. Very captivating reading........
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