Free-Radical-Induced DNA Damage and Its Repair: A Chemical Perspective By Clemens von Sonntag

Product Description

Understanding of the molecular basis of DNA damage and its repair has increased dramatically in recent years, and substantial knowledge now exists concerning the products arising from free-radical attack on DNA. Free-radical DNA damage may lead to mutations, cancer, and cell death. Free radicals have various sources, notably ionizing radiation and oxidative stress. In radiotherapy for cancer and with some anticancer drugs, use is made of cell death by excessive DNA damage. The mechanisms leading to products of free-radical attack which have been studied in models and with small double-stranded DNA fragments are discussed in detail, and the basics of the underlying free-radical chemistry are dealt with in separate chapters.

Product Details

* Amazon Sales Rank: #1645438 in Books
* Published on: 2006-01-09
* Number of items: 1
* Binding: Hardcover
* 523 pages

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About the Author

Born in 1936, Chemistry at Heidelberg, Vienna and Karlsruhe, PhD (1964 with D. Schulte-Frohlinde) and Habilitation (1970) at Karlsruhe. Postdoc with F. S. Dainton (Leeds). 1960-1970 Nuclear Research Center Karlsruhe, 1970- 2001 Max-Planck-Institut für Strahlenchemie, Mülheim. After retirement continuing collaboration with the Leibniz-Institut für Oberflächenmodifizierung (IOM), Leipzig.